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February 20, 2025

The 4 Axes of Drug Development Readiness

Clinical, CMC, Finance, Knowledge, Oral Drugs, Parenteral Drugs, Patent, Pharmaceutical Development, Pharmaceutical Manufacturing, Planning, Pre-Clinical, Raw Materials, Risk Management

Stuart R. Gallant, MD, PhD In the earliest stages of drug research, scientists conduct bench experiments at a university or in a corporate pharmaceutical research…

Stuart Gallant
August 9, 2023

What The Washington Post Got Wrong About Doctors

Finance, Insurance, Medical, Pharma Economics

Stuart R. Gallant, MD, PhD The Washington Post just published an article by Andrew Van Dam, “How much money do doctors really make and why…

Stuart Gallant
June 19, 2023

Leased Lab Space

Finance, Logistics, Pharma Economics, Pharmaceutical Development, Planning

Stuart R. Gallant, MD, PhD In the last two decades, startup pharmaceutical companies have become increasingly frugal with investment capital.  One of the ways to…

Stuart Gallant
March 26, 2023

Investing in Pharmaceutical Startups

Finance, Patent, Pharmaceutical Development, Pharmacy, Planning, Pre-Clinical

Stuart R. Gallant, MD, PhD PharmaTopo recently posted on the topic of founding a pharmaceutical startup.  Today’s post looks at pharmaceutical startups from the investor’s…

Stuart Gallant
March 11, 2023

Founding a Pharma Startup

Finance, Patent, Pharmaceutical Development, Pharmacy, Planning, Pre-Clinical

Stuart R. Gallant, MD, PhD In the late 1950s, electronics scientists and engineers like Robert Noyce, Gordon Moore, and Eugene Kleiner invented the idea that…

Stuart Gallant
January 18, 2023

Solving Drug Shortages

CMC, Finance, Marketed Products, Pharma Economics, Pharmaceutical Manufacturing, Pharmacy, Planning, Portfolio Management, Risk Management

Stuart R. Gallant, MD, PhD Imagine that you have an infection, and you need a common antibiotic, but you cannot find a drugstore that is…

Stuart Gallant
September 24, 2022

Anti-TNF Medications

Clinical, Finance, Marketed Products, Medical, Parenteral Drugs, Patent, Pharma Economics, Pharmaceutical Development, Pharmacy

Stuart R. Gallant, MD, PhD I have a weakness for old Hollywood movies.  The movie still that appears above this paragraph depicts John Carradine in…

Stuart Gallant
August 25, 2022

Pharmaceutical Design Focus:  Clot Busters (2 of 2)

Clinical, CMC, Finance, Marketed Products, Medical, Parenteral Drugs, Patent, Pharma Economics, Pharmaceutical Development, Pharmaceutical Manufacturing, Pharmacy, Portfolio Management, Raw Materials

Stuart R. Gallant, MD, PhD In the first part of this post, we looked at urokinase.  In the second part, we will look at tissue…

Stuart Gallant
August 25, 2022

Pharmaceutical Design Focus:  Clot Busters (1 of 2)

Clinical, CMC, Finance, Marketed Products, Medical, Parenteral Drugs, Patent, Pharma Economics, Pharmaceutical Development, Pharmaceutical Manufacturing, Pharmacy, Portfolio Management, Raw Materials

Stuart R. Gallant, MD, PhD This November will be the 35th anniversary of the approval of tissue plasminogen activator (tPA, alteplase) a leading treatment for…

Stuart Gallant
August 14, 2022

Amazon’s Push Into Healthcare

Finance, Insurance, Medical, Pharma Economics, Pharmacy

Stuart R. Gallant, MD, PhD I was intrigued by Amazon’s recent purchase of One Medical for $3.9B in cash. Amazon is implementing a strategy to…

Stuart Gallant
August 9, 2022

Pharmaceutical Supply Chain Risk Management

CMC, Finance, Logistics, Pharmaceutical Development, Pharmaceutical Manufacturing, Planning, Risk Management

Stuart R. Gallant, MD, PhD As pharmaceutical supply chains have become global, the risk management of drug supply has become increasingly complex.  Recently, I was…

Stuart Gallant
August 6, 2022

Pharmaceutical Decision Making and Fundraising

Clinical, Finance, Pharma Economics, Pharmaceutical Development, Planning, Portfolio Management, Pre-Clinical, Risk Management, Uncategorized

Stuart R. Gallant, MD, PhD Within pharmaceutical development, there are two types of go-no-go decisions:  1) clinical and 2) financial.  These decisions are linked together…

Stuart Gallant
March 22, 2022

Pharmaceutical Design Focus:  Factor VIII (2 of 2)

Clinical, CMC, Finance, Marketed Products, Parenteral Drugs, Patent, Pharma Economics, Pharmaceutical Manufacturing

Stuart R. Gallant, MD, PhD In the first part of this two-part post, we looked at the biochemistry of clotting factor Factor VIII and the…

Stuart Gallant
March 6, 2022

Financial Metrics of Pharmaceutical Companies (2 of 2)

Finance, Pharma Economics, Pharmaceutical Manufacturing

Stuart R. Gallant, MD, PhD In the second part of this two-part post, the topic of valuation will be discussed, followed by how some of…

Stuart Gallant
March 6, 2022

Financial Metrics of Pharmaceutical Companies (1 of 2)

Finance, Pharma Economics, Pharmaceutical Manufacturing

Stuart R. Gallant, MD, PhD This two-part post looks at pharmaceutical companies and how they are financially structured to survive in a competitive market, to…

Stuart Gallant

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